Group Leader, MRC Laboratory of Molecular Biology
Dr Philipp Holliger works on evolutionary approaches to protein engineering and functional genomics within the MRC Laboratory of Molecular Biology. His main interests are in vitro evolution and its application to protein engineering and functional genomics. In vitro selection methods are powerful tools for the investigation of protein and nucleic acid structure and function at the molecular level.
His group's work is aimed at:
- Creating novel selection technologies for applications in protein engineering and functional genomics.
- Their application to specific problems e.g. the the investigation of the molecular basis of existing phenotypes or the directed evolution of novel phenotypes.
- The application of selection technologies in combination with array screening to the annotation of gene function on a genome-wide scale.
Philipp graduated in 1990 in natural sciences from the Swiss Federal Institute of Technology (ETH) Zürich. He then moved to the MRC Centre for Protein Engineering, Cambridge, to join the group of Dr Greg Winter, FRS, where he obtained his PhD in 1994 under the joint supervision of DrWinter and Professor T.J. Richmond, ETH Zürich. He stayed with Dr. Greg Winter as a postdoc, to continue the work on diabodies as well as on the structure and function of g3p, the main infectivity protein of filamentous bacteriophages. In 1999 he was appointed junior group leader at the CPE and in 2000 he became a group leader at the MRC Laboratory of Molecular Biology.