26 April meeting of the Dowling Policy Fellowship

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CSaP's Dowling Policy Fellowship, named after Professor Dame Ann Dowling, is a small group of supporters who are committed to the Centre's mission to help public policy-making address the major challenges of the 21st century through drawing more effectively on the best research, evidence and expertise. Fellows have a track record of leadership and innovation across a range of industries, and have a common interest in advancing policies to support science, innovation and entrepreneurship in the public interest.

The Fellowship's fourth meeting will take place in Jesus College, Cambridge, on Friday 26 April 2024. The visit is designed to introduce cutting-edge research, stimulate discussion in areas of common interest and identify opportunities for future collaboration and engagement. The broad theme for the afternoon is biotechnology with a focus on engineering and synthetic biology and the schedule for the visit is below.

Contact: Karri Aston on k.aston@jbs.cam.ac.uk or 07720 837603

  • 26 Apr 2024 11:00 – 11:15

    Tea and coffee on arrival

    Webb Library, West Court, Jesus College, 22 Jesus Lane, Cambridge CB5 8BQ
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  • 26 Apr 2024 11:15 – 12:15

    Meeting with Professor Mark Howarth, Sheild Professor of Pharmacology, Department of Pharmacology, University of Cambridge

    mh2186@cam.ac.uk

    Make connections for life: synthetic biology and superglues from bacteria

    Mark's lab, the Howarth Group, takes inspiration from the extraordinary molecular features from the natural world to develop new approaches for disease prevention and therapy. By engineering and evolving proteins and cellular systems, his group projects range from fundamental analysis of protein interactions through to clinical application.

    Mark helped to found SpyBiotech in 2017 and several of the lab’s alumni have founded their own companies, with Mark acting as Translational Champion for the Department.

    Suggested pre-reading:

    Webb Library, West Court, Jesus College, 22 Jesus Lane, Cambridge CB5 8BQ
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  • 26 Apr 2024 12:30 – 13:30

    Lunch discussion

    ls299@cam.ac.uk

    Dr Lalitha Sundaram, Senior Associate Researcher at the Centre for the Study of Existential Risk will be in conversation with attendees over lunch. Lalitha's research is in the area of bio-risk, with a particular emphasis on regulation and governance. She investigates risks – real or perceived – surrounding emerging biotechnologies such as synthetic biology. She is currently on a partial secondment to FCDO in the Arms Control and Disarmament Research Unit.

    Awaiting suggested readings

    Radegund Hall, West Court, Jesus College, 22 Jesus Lane, Cambridge CB5 8BQ
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  • 26 Apr 2024 13:45 – 14:45

    Meeting with Dr Jake Harris, Associate Professor, Head of Chromatin & Memory Group, Department of Plant Sciences, University of Cambridge

    cjh92@cam.ac.uk

    Jake Harris leads the Harris Lab which is exploring the question "Can we use epigenome engineering approaches to ‘vaccinate’ plants so that they are more resilient?" His lab employs a range of cutting-edge approaches (molecular, [epi]genomic, computational) to engineer biology and address basic questions with potential implications in health and agriculture. Jake will provide a brief overview of the field and introduce his research.

    Awaiting suggested readings

    Webb Library, West Court, Jesus College, 22 Jesus Lane, Cambridge CB5 8BQ
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  • 26 Apr 2024 14:45 – 15:00

    Refreshment break

    Webb Library, West Court, Jesus College, 22 Jesus Lane, Cambridge CB5 8BQ
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  • 26 Apr 2024 15:00 – 16:00

    Meeting with Dr Somenath Bakshi, Associate Professor, Department of Engineering, University of Cambridge

    sb2330@eng.cam.ac.uk

    Systems analysis of antimicrobial response in bacteria through time-resolved single-cell phenotyping

    The rapid spread of antimicrobial resistance (AMR) has created a world-wide antibiotic crisis. At the Bakshi Laboratory of Systems and Synthetic Microbiology, we focus on unravelling the genetic and metabolic factors that lead to the development of antimicrobial resistance in bacteria.

    A key property of microbial systems is cell-to-cell heterogeneity, which emerges from noisy biochemical processes. We are analysing how the population heterogeneity in the metabolism, physiology, and gene-expression in microbial systems impacts the response of microbes towards antimicrobials and how rare outliers in the population provide protection from the treatment and cause recurrent infections and evolution of resistance.

    Utilising high-throughput microfluidics, time-resolved microscopy, and machine-learning models for image analysis, we scrutinise the dynamic responses of individual cells to antibiotic treatments. These analyses connect cellular responses to each cell's unique physiological history, yielding unprecedented insights into antimicrobial responses and resistance mechanisms.

    A recent focus of our lab involves exploring alternative antimicrobials, such as bacteriophage viruses, to combat resistance spread in microbial populations. We have devised a groundbreaking assay to monitor individual phage infections on bacterial cells, which promises to accelerate phage therapy development by identifying effective phages and dissecting phage resistance mechanisms.

    Suggested pre-readings:

    .

    Webb Library, West Court, Jesus College, 22 Jesus Lane, Cambridge CB5 8BQ
    View on map

  • 26 Apr 2024 16:00 – 16:30

    Drinks reception and networking

    Should the weather turn against us, drinks will be served in the Webb Library.

    West Court Courtyard, Jesus College, University of Cambridge

    CSaP have booked shared taxis to the station departing at 16:30 for attendees wishing to catch the 17:09 train for London Kings Cross.

  • 26 Apr 2024

    Biographies of Dowling Policy Fellows and guests

    Amelia Armour joined Amadeus Capital Partners in 2009 and is a Partner in the Early Stage Fund. She is a Director on several boards including Xampla, who have developed a plant-based material to replace single-use plastics; iPronics who are building the world’s first programmable photonic processor; Riverlane a developer of the operating system for error corrected quantum computers and SLAMcore, a spin-out from Imperial College, developing spatial intelligence for autonomous robotics and drones. Prior to Amadeus, she worked at Barclays Investment Bank in the structured capital markets team and at the Commonwealth Bank of Australia in Sydney. She qualified as a chartered accountant with Deloitte in London in the corporate tax department. Amelia holds a BSc in Chemistry and Biology from Durham University.

    Cinzia Basile is the Chairman of My Community Bank. In her role she has led the company to its fast growth with the use of fintech. Cinzia set up and ran the Credit Suisse Investment Bank multi-asset investment management business, Custom Markets. Cinzia currently sits on the board of several financial institutions across Europe including Eurobank, Nikko Europe Asset Management, Creditis Servizi Finanziari and Zenith Service S.p.A. Cinzia is also the Chair and Member of several committees including Risk, Pricing, Audit, Remuneration and Stewardship.

    Hayoung Choi is a third-year undergraduate in the Department of Genetics with a distinct passion for environmental policy and food security. This passion aligns well with her interest in plant science. She also places significance on philosophical discussions about regulatory science, which involves the critical evaluation of the risks and benefits associated with technologies. Serving as a workshop team lead last year, she found it rewarding to facilitate discussions between the realms of science and science policy. This year, as President of the Cambridge University Science and Policy Exchange (CUSPE), she looks forward to strengthening the alumni network and forging connections with other science or science policy institutions.

    Vanessa Colomar is a co-founder of Invoke Capital which forms, funds and develops fundamental technologies, often disrupting established methodologies and developing multi-billion pound businesses in the process. Invoke Capital created Darktrace, a leading AI cybersecurity company and was instrumental in getting the company up and running from inception, as well as helping it to scale rapidly prior to taking it public on the LSE in 2022. Vanessa has decades of experience helping founders create and scale technology companies. Throughout her career she has sat at the intersection of ideas and their development in a variety of roles spanning media, politics, technology, business, academia and the law. Invoke capital also formed Luminance, an AI platform that is changing the way lawyers work with documents and contracts. Invoke was an early investor in the Nasdaq-listed Sophia Genetics, which is transforming personalised medicine and cancer treatment. Her areas of expertise are in the practical application and policy implications of Artificial Intelligence and cyber security.

    Oscar Hinze works as a Policy Adviser in the engineering biology policy team in the Department for Science, Innovation and Technology. He has worked on science and technology policy for several years, in DSIT and previously in BEIS. Previous roles include being the lead for quantum readiness in the Office for Quantum. He has also worked on investment and research collaboration policy in quantum technologies and advanced robotics, as well as cross-cutting export control issues. Before joining BEIS, Oscar worked as a crime and policing analyst at the Home Office. He holds a BSc in Astrophysics from University College London.

    Filippo Lanza is Chief Investment Officer at Numen Capital LLP, a London-based multi strategy manager deploying a fundamental credit approach to event driven and credit opportunities. With offices in London and Malta, Numen Capital's expertise focuses on investments falling within the liquid aspect of the Credit spectrum. Filippo has also been a Venture Investor in several start-ups in EduTech across the UK and USA, and FinTech in the UK since 2017. Previous roles include Main Portfolio Manager at Ferox Capital LLP, Head of Credit Trading Europe at Lehman Brothers and Associate in the European Credit Trading Unit at JPMorgan Chase.

    Dr Alex McGill is based in the Homeland Security Group – a part of the Home Office – where he oversees the delivery of research projects in the physical and biological sciences. This is his second posting as part of the Civil Service Science & Engineering Fast Stream, having previously worked on AI policy in the Ministry of Defence. His academic background is in mathematics and theoretical physics.

    Nathan Medlock became a Managing Partner of the growth equity firm Planet First Partners in September 2023. He was a Partner in the Technology Team of Zouk Capital from 2013 to July 2023, where he led and managed the growth capital funds investing in sustainable technology companies. Before joining Zouk, Nathan was a Partner at Galaxis Capital where was active in operational roles with Private Equity backed companies, including that of CEO in a Swedish listed mining company and CFO of a private US biotech company. Prior, he worked at Warburg Pincus in a direct investment role where he invested, managed and restructured over a $1bn of investments in European growth capital companies. Prior to those roles, Nathan was with Lehman Brothers where he was a director in the private equity division. Nathan holds a Master of Business Administration with Honours from The Wharton School of the University of Pennsylvania, and a Masters of Engineering and a Bachelor of Science in Mechanical Engineering and Energy Systems (Nuclear) from the University of Manchester.

    Evelyn Murrell is a Science and Engineering Fast Streamer in the UK civil service. Her current role is in Government and Strategic Partnerships at the Wellcome Trust. Prior to this, she worked at the UK Health Security Agency and in the International Science Team at DEFRA. Before working in government, she completed an Integrated Master's in Biology and Chemistry, including a research project focused on antibiotic resistance.

    CSaP Staff

    Karri Aston manages the Policy Leaders Fellowship programme at CSaP. She is responsible for termly meetings of the Policy Leaders Fellows, matching Fellows to relevant academics and developing the Fellowship’s interactions with other organisations. She is also responsible for the Horn Fellowship and the Dowling Policy Fellowship. Prior to joining CSaP in 2021, Karri worked at the Centre for Geopolitics, a research centre in the Department of Politics and International Studies (POLIS), University of Cambridge for two years as the Centre Coordinator. Karri has experience in the charity sector, fundraising, government relations and association management. Her first degree is in Political Science and she has an International MBA.

    Jacob Bradbury became a Policy Intern at CSaP in April 2024. He is a DPhil student in Chemical Biology at the University of Oxford. His research focuses on the development of novel antimicrobials using both medicinal chemistry and chemical biology techniques at the Ineos Oxford Institute for Antimicrobial Research and the Department of Pharmacology.

    Kate Johnson joined CSaP in October 2022 as the Policy Leaders Fellowship Programme Coordinator. Previously, she worked in the Student Support Services team at the University of Leicester. Kate has front-of-house management experience in the luxury hospitality sector and has held administrative positions in the Building Surveying and Engineering sector. She supports the organisation of termly meetings of the Policy Leaders Fellows and assists with the Horn Fellowship and the Dowling Policy Fellowship.